A new method for determination of mandelic acid excretion at low level styrene exposure
نویسندگان
چکیده
منابع مشابه
Enzymatic Method for Determination of Vanillyl Mandelic Acid.
An enzymatic method is described for the measurement of vanillyl mandelic acid (VMA). The method utilizes an L-mandelic acid dehydrogenase preparation from Pseudomonas fluorescens A-312 to catalyze the transformation of VMA to vanillin. The method is specific for VMA becauseonly the final product, vanillin, will absorb maximally at 350 m/L. The results compare favorably with the method of Pisan...
متن کاملEffect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour.
The effect of a dose of alcohol on the kinetics of mandelic acid excretion in four volunteers exposed to 220 mg/m3 styrene has been investigated under controlled exposure chamber conditions. Ethanol inhibited the excretion of mandelic acid, so that the peak excretion was delayed from the end of the exposure period until three hours afterwards. One hour after administration of ethanol blood mand...
متن کاملDetermination of low level exposure to volatile aromatic hydrocarbons and genotoxic effects in workers at a styrene plant.
OBJECTIVES Low exposures to volatile aromatic hydrocarbons and cytogenetic effects in peripheral white blood cells were determined in 25 healthy workers employed in different areas of a styrene production plant in the former German Democratic Republic. The results were compared with 25 healthy unexposed controls (matched for age and sex) employed in the same company. METHODS The concentration...
متن کاملThe urinary excretion of mandelic acid administered intravenously to cats.
MANDELIc acid, when administered to animals, may be recovered almost quantitatively from the urine. Moreover, when mandelic acid appears in the body as the result of metabolic processes, it is supposed to be excreted without further change [Knoop, 1905; Dakin, 1922; Quick, 1928]. Neubauer [1909], Neubauer & Fischer [1910], Neubauer & Gross [1910] and Neubauer & Warburg [1910] claimed that after...
متن کاملUrinary vanillyl-mandelic acid (VMA) excretion by chronically anaemic children.
Hypoxia has been regarded as one of the many factors stimulating augmented catecholamine biosynthesis (Vogt, 1960). Plasma levels of epinephrine and norepinephrine were found to be increased in newborns with the respiratory distress syndrome or placental insufficiency (Cheek, Malinek, and Fraillon, 1963). Infants with severe heart failure eliminate in the urine twice as much metanephrine, norme...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1973
ISSN: 1351-0711
DOI: 10.1136/oem.30.4.390